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4.2 Gastric adenocarcinoma and gastric cancer The process of developing gastric cancer involves several stages, beginning with the change from normal mucosa to chronic superficial gastritis (non-atrophic gastritis)

In some patients, this activation becomes so massive that cytokine storm develops, resulting in thrombotic tendency and multi-organ failure, and eventually causing death [5, 6]

Ingestion of strong bases (alkali) can cause a thick & slimy vomitus that may contain blood

doi: 10.1016/j.vaccine.2017.02.020 72 PansareV.HejaziS.FaenzaW.PrudhommeR

10.1167/iovs.65.11.39 151

This implies, rather, folate polyglutamate derivatives must be hydrolyzed to their corresponding monoglutamate forms by the enzyme glutamate carboxypeptidase II ( FOLH1 , folate hydrolase 1) in human intestine, upon ingestion